Gougerot sjögren wiki

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Waldenström's hyperglobulinemic purpura seems to have an autoimmune origin (the subject produces antibodies against his own tissues). These pathophysiological findings open up interesting prospects for the treatment of GSS.

What are the symptoms of Gougerot-Sjögren’s disease?

Symptoms are dominated by ocular and oral involvement, which are common in 90% of patients with GMS.

Patients complain of difficulty swallowing, a lack of stability in removable dentures, the appearance of cavities, chronic burning of the oral mucosa, intolerance to spicy or acidic foods, an inability to eat dry foods or to speak continuously for several minutes.

The onset of symptoms is insidious and progresses slowly. The tongue is red, depilated and cracked , and the saliva lake usually present on the floor of the mouth is often non-existent.

Candidiasis is therefore very common in GSS, affecting up to 70% of patients and presenting in a variety of forms:acute pseudomembranouscandidiasis (thrush), erythematous candidiasis, angular cheilitis (perlachia), subprosthetic stomatitis, etc.

What naturopathic advice do you have for reducing the symptoms of autoimmune Gougerot-Sjögren’s disease?

If you suffer from autoimmune Gougerot-Sjögren’s disease, you know how difficult the symptoms can be to manage.

These measures can be used alongside the medical treatment prescribed by your doctor to improve your general well-being.

Avoid mucosal drying environments:

Learn to recognise and avoid places with low humidity (shops and offices with air conditioning),exposure to wind, dusty places, irritating substances and cigarette smoke.

Taking care of your oral and dental hygiene:

Oral hygiene must be rigorous and regular!

The role of water :

Replacing the missing secretion can be easily achieved by taking frequent sips of water.

gougerot sjögren wiki

Since the autonomic nervous system does not do its job properly, this deficiency could be linked to autoantibodies that turn against M3 muscarinic receptors (which control water secretion from the lacrimal and salivary glands via membrane expression of aquaporin 5, which also appears to be defective in the case of GAS).

Ultimately, dryness would be due to glandular destruction, but also to a deficit in the autonomic nervous system and a defect in the membrane expression of aquaporin 5.

These changes tend to cause obstruction of the vessels and more specifically the alteration of their wall following an antigen-antibody immune reaction. Lancet 2005

  • Steinfeld S, Cogan E, King LS, Agre P, Kiss R, Delporte C. Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjogren’s syndrome patients.

    There are also other saliva substitutes such as polyethylene oxide or polysaccharide extracts from flaxseed.

    The former appears to be more effective than methylcellulose in reducing the symptoms of xerostomia, while the latter gives satisfactory results in around 75% of patients. Ann Med Intern 2003

  • Moutsopoulos HM.

    Sjogren’s syndrome: autoimmune epithelitis. This information is essential for understanding the extent of Gougerot-Sjögren’s syndrome and the need for appropriate treatment.

    What is the impact of autoimmune diseases on children of African descent?

    In an in-depth study published in 2024 in thePediatric Rheumatology Online Journal, researchers examined mixed connective tissue autoimmune diseases and other autoimmune diseases in children of African descent in the French West Indies.

    Three patients developed systemic lupus erythematosus after more than 10 years of follow-up. Histologically, the syndrome is characterised by lymphoid infiltration of the exocrine glands, particularly the salivary and lacrimal glands, and the biological production of large quantities of autoantibodies (FAN, anti-SSA, anti-SSB, rheumatoid factor).

    This results in the appearance of purpura (blue-violet spots) in the skin, recurring urticaria, skin ulcers, glomerulonephritis, and multiple neuritis (inflammatory damage to the peripheral nerves).

    Regarding complications related to lymphoma, the following medical data can be put forward. Citric acid, for example, stimulates taste, while chewing gum stimulates both.

    Jaborandi mother tincture:

    The pilocarpine naturally contained in Jaborandi officinal is a cholinergic muscarinic receptor agonist.

    J Dent Res 1986

  • Johansson G, Andersson G, Attstrom R, Glantz PO, Larsson K. The effect of Salinum on the symptoms of dry mouth: a pilot study. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. If it is insufficient, the chewing gum will stick to the teeth.

    The localization of this phenomenon is sometimes limited to two or three fingers on each hand. There is also atrophy of certain areas of the back of the tongue (filiform papillae).

    • Premature

    In one in two patients, there is a decrease in hearing acuity during the course of the disease. Am J Med 1991

  • Vissink A, De Jong HP, Busscher HJ, Arends J, Gravenmade EJ.

    Wetting properties of human saliva and saliva substitutes. Arthritis Rheum 1996

  • RMD Open. In medical terms, this is called paroxysmal digital ischemia, which manifests itself by the successive appearance of episodes of pallor and cyanosis (a blue-gray color indicating a lack of oxygen in the fingers). However, water does not adequately moisten or lubricate the oral mucosa and teeth.

    Stimulate your salivary secretion:

    When residual salivary secretion is high enough, chewing sugar-free chewing gum is a good stimulus.

    At the start of the disease, lymphocyte infiltration is focaland some glands are still intact. These patients generally complain of continuous fatigue, low-grade fever, muscle pain, joint pain, and Raynaud's syndrome. It reveals that this autoimmune disease, which manifests itself mainly as dry eyes and mouth, mainly affects women, with an average age of 60 for primary syndrome and 56 for syndrome associated with other autoimmune diseases.